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The River Clyde became an important source of inspiration for artists, such as John Atkinson Grimshaw, willing to depict the new industrial era and the modern world. Glasgow's population had surpassed that of Edinburgh by 1821. By the end of the 19th century the city was known as the "Second City of the Empire" and by 1870 was producing more than half Britain's tonnage of shipping and a quarter of all locomotives in the world. During this period, the construction of many of the city's greatest architectural masterpieces and most ambitious civil engineering projects, such as the Loch Katrine aqueduct, Subway, Tramway system, City Chambers, Mitchell Library and Kelvingrove Art Gallery and Museum were being funded by its wealth. The city also held a series of International Exhibitions at Kelvingrove Park, in 1888, 1901 and 1911, with the Empire Exhibition subsequently held in 1938.

The 20th century witnessed both decline and renewal in the city. After World War I, the city suffered from the impact of the Post-World War I recession and from the later Great Depression, this also led to a rise of radical socialism and the "Red Clydeside" movement. The city had recovered by the outbreak of World War II and grew through the post-war boom that lasted through the 1950s. However by the 1960s, a lack of investment and innovation led to growing overseas competition in countries like Japan and Germany which weakened the once pre-eminent position of many of the city's industries. As a result of this, Glasgow entered a lengthy period of relative economic decline and rapid deindustrialisation, leading to high unemployment, urban decay, population decline, welfare dependency and poor health for the city's inhabitants. There were active attempts at regeneration of the city, when the Glasgow Corporation published its controversial Bruce Report, which set out a comprehensive series of initiatives aimed at turning round the decline of the city. There are also accusations that the Scottish Office had deliberately attempted to undermine Glasgow's economic and political influence in post-war Scotland by diverting inward investment in new industries to other regions during the Silicon Glen boom and creating the new towns of Cumbernauld, Glenrothes, Irvine, Livingston and East Kilbride, dispersed across the Scottish Lowlands, in order to halve the city's population base.

However, by the late 1980s, there had been a significant resurgence in Glasgow's economic fortunes. The 'Glasgow's miles better' campaign, launched in 1983, and opening of the Burrell Collection in 1983 and Scottish Exhibition and Conference Centre in 1985 facilitated Glasgow's new role as a European centre for business services and finance and promoted an increase in tourism and inward investment. The latter continues to be bolstered by the legacy of the city's Glasgow Garden Festival in 1988, its status as European City of Culture in 1990, and concerted attempts to diversify the city's economy. This economic revival has persisted and the ongoing regeneration of inner-city areas, including the largescale Clyde Waterfront Regeneration, has led to more affluent people moving back to live in the centre of Glasgow, fuelling allegations of gentrification. The city now resides in the Mercer index of top 50 safest cities in the world and is considered by Lonely Planet to be one of the world's top 10 tourist cities. Despite Glasgow's economic renaissance, the East End of the city remains the focus of severe social deprivation. A Glasgow Economic Audit report published in 2007 stated that the gap between prosperous and deprived areas of the city is widening. In 2006, 47% of Glasgow's population lived in the most deprived 15% of areas in Scotland, while the Centre for Social Justice reported 29.4% of the city's working-age residents to be "economically inactive". Although marginally behind the UK average, Glasgow still has a higher employment rate than Birmingham, Liverpool and Manchester.

It is common to derive the name Glasgow from the older Cumbric glas cau or a Middle Gaelic cognate, which would have meant green hollow. The settlement probably had an earlier Cumbric name, Cathures; the modern name appears for the first time in the Gaelic period (1116), as Glasgu. However, it is also recorded that the King of Strathclyde, Rhydderch Hael, welcomed Saint Kentigern (also known as Saint Mungo), and procured his consecration as bishop about 540. For some thirteen years Kentigern laboured in the region, building his church at the Molendinar Burn, and making many converts.